Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Red Light ALA PDT Well Tolerated in AK Treatment

Photomed Laser Surg; ePub 2017 Dec 11; Paragh, et al

Red light 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) of actinic keratosis (AKs) is very well tolerated with the 2-step irradiance protocol, according to a recent study. Researchers performed a retrospective chart review to assess the level of pain during AK treatment by red light PDT (n=99). Natural density filter was used to reduce the irradiance of the light source and initially 10 J/cm2 dose was delivered at 35 mW/cm2 and then, 65 J/cm2 dose was delivered at 70 mW/cm2. Pain level was measured using a 10-point visual analog scale at 3 points during the procedure. They found:

  • Pain was low to moderate in most patients (mean ± standard error of the mean pain score: 2.35 ± 0.19).
  • Higher pain was seen mid-procedure vs at the beginning and at the end of PDT.
  • There was no significant difference in pain perception between genders and different treatment areas.

Citation:

Paragh G, Zeitouni NC. Two-step irradiance treatment can achieve excellent pain control during red light 5-aminolevulinic acid photodynamic therapy for actinic keratosis. [Published online ahead of print December 11, 2017]. Photomed Laser Surg. doi:10.1089/pho.2017.4351.

This Week's Must Reads

Timing and Number of cSCCs in Transplant Recipients, JAMA Dermatology; ePub 2018 May 16; Puza, et al

Therapeutic Choices for Psoriasis and Mental Health, J Dermatolog Treat; ePub 2018 May 14; Salame, et al

Rare, Severe Mucocutaneous Reaction Investigated, J Invest Dermatol; ePub 2018 May 11; Micheletti, et al

Skin Manifestations in Graft-Versus-Host-Disease, J Am Acad Dermatol; 2018 Jun; Kim, Schmelkin, et al

Increased Risk of Skin Cancer Found in the Military, J Am Acad Dermatol; 2018 Jun; Riemenschneider, et al

Must Reads in Actinic Keratosis

Red Light ALA PDT Well Tolerated in AK Treatment, Photomed Laser Surg; ePub 2017 Dec 11; Paragh, et al

Cost of Managing AK Varies by Region, JAMA Dermatol; ePub 2017 Mar 1; Kirby, et al

Physician Wording Role in Seeking AK Treatment, JAMA Dermatol; ePub 2017 Jan 18; Berry, Butt, et al

Acantholysis in SCC Not Considered High Risk, J Am Acad Dermatol; ePub 2016 Nov 23; Ogawa, et al

Prevalence of Nonmelanoma Skin Cancers High in VHA, Dermatol Surg; ePub 2016 Jul 25; Yoon, Phibbs, et al