Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Oral Antibacterial Therapy for Acne Vulgaris

Am J Clin Dermatol; 2017 Aug; Bienenfeld, et al

Tetracyclines, macrolides, and trimethoprim/sulfamethoxazole are effective and safe in the treatment of moderate-to-severe inflammatory acne, according to recent evidenced-based review. A systematic literature review was conducted to identify randomized controlled clinical trials, systematic reviews, and meta-analyses evaluating the efficacy of oral antibiotics for acne. Overall, 41 articles that examined oral antibiotics compared with placebo, another oral therapy, topical therapy, alternate dose, or duration were included in this study. Researchers found:

  • Superior efficacy of one type or class of antibiotic could not be determined. Therefore, the choice of antibiotic is generally based on the side-effect profile.
  • The combination of oral antibiotics with a topical therapy is superior to oral antibiotics alone.
  • Due to increasing resistance to antibiotics, dermatologists should heed consensus guidelines for their appropriate use.

Citation:

Bienenfeld A, Nagler AR, Orlow SJ. Oral antibacterial therapy for acne vulgaris: An evidence-based review. Am J Clin Dermatol. 2017;18(4):469-490. doi:10.1007/s40257-017-0267-z.

This Week's Must Reads

Prevalence and Type of Genital Lesions in OTRs, JAMA Dermatology; ePub 2018 Jan 31; Nadhan, et al

Use of UV Radiation for Medical, Cosmetic Purposes, J Clin Aesthet Dermatol; 2018 Feb; Sampson, et al

Melanoma Risk Assessed in Melanoma-Prone Families, J Invest Dermatol; ePub 2018 Feb 2; Tucker, Elder, et al

Polycystic Ovary Syndrome Linked with HS, J Invest Dermatol; ePub 2018 Feb 4; Garg, et al

Two Surgeries Effective for Merkel Cell Carcinoma, J Am Acad Dermatol; ePub 2018 Feb 3; Singh, et al

Must Reads in Acne

New Technology for Acne Evaluations Reliable, JAMA Dermatol; ePub 2017 Dec 20; Singer, et al

Acne Vulgaris: Higher Incidence in Western Nations, Clin Dermatol; 2018 Jan/Feb; Melnik

G2A Regulates Immune Responses to P. Acnes, Ann Dermatol; 2017 Dec; Park, Agak, et al

Study: Acne Vulgaris Affects Quality of Life, J Cosmet Dermatol; 2017 Dec; Gokalp, et al

Factors Affecting Severity of Adult Acne, J Dermatolog Treat; 2017 Dec; Chlebus, et al