Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

sLOX-1 in Ischemic Stroke & Transient Ischemic Attack

J Am Heart Assoc; ePub 2018 Jan 12; Skarpengland, et al

Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels are elevated in patients with ischemic stroke and transient ischemic attack (TIA) independent of cause and time since the ischemic event, a recent study found. Plasma sLOX-1 (n=232) and carotid plaque OLR1 gene expression (n=146) were evaluated in patients referred for carotid endarterectomy, as well as in health control plasma (n=81). Patients were categorized according to presence of acute ischemic stroke or TIA (n=35), ≤7 days, >7 days ≤3 months (n=90), >3 months (n=40), or no reported symptoms (n=67). Researchers found:

  • Patients with carotid atherosclerosis had increased plasma sLOX-1 levels compared with controls.
  • Plaque OLR1 mRNA levels were increased in carotid plaques compared with nonatherosclerosis vessels.
  • Patients with an acute ischemic stroke caused by atrial fibrillation had raised sLOX‐1 levels comparable to those with an acute ischemic cerebral event related to carotid atherosclerosis.
  • There were no differences in sLOX plasma levels or OLR1 gene expression when analyzed according to the time since relevant cerebral ischemic symptoms.
  • Patients with severe carotid atherosclerosis without any previous ischemic events had raised sLOX-1 levels.


Skarpengland T, Skjelland M, Kong XY, et al. Increased levels of lectin-like oxidized low-density lipoprotein receptor-1 in ischemic stroke and transient ischemic attack. [Published online ahead of print January 12, 2018]. J Am Heart Assoc. doi:10.1161/JAHA.117.006479.

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