Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lipoproteins & CV Outcomes in Dialysis Patients

J Clin Lipidol; ePub 2017 Dec 26; Kaysen, et al

Low-density lipoprotein (LDL) and apoliporprotein (Apo) B are inversely associated with infectious events in dialysis patients; however, lipoproteins are not associated with cardiovascular outcomes, a recent study found. Researchers examined associations between serum apolipoprotein (Apo) A1, B, C2, C3, high-density lipoprotein (HDL) and LDL cholesterol and triglyceride levels and infectious mortality or hospitalization, CV mortality or hospitalization, and all-cause mortality in 433 prevalent patients receiving hemodialysis (HD). They found:

  • Median follow-up for all-cause mortality was 2.7 years.
  • 179 (41%) patients had an infection-related event.
  • Higher Apo A1, Apo B, and Apo C3 are associated with lower all-cause mortality.
  • Lipoproteins are not associated with CV outcomes.


Kaysen GA, Grimes B, Dalrymple LS, et al. Associations of lipoproteins with cardiovascular and infection-related outcomes in patients receiving hemodialysis. [Published online ahead of print December 26, 2017]. J Clin Lipidol. doi:10.1016/j.jacl.2017.12.007.

This Week's Must Reads

Detection & Management of Resistant Hypertension, Hypertension; ePub 2018 Sep 13; Carey, et al

Does Aspirin Prevent CV Events in Older Adults?, N Engl J Med; ePub 2018 Sep 16; McNeil, et al

Timing of ICD Placement From Last Hospitalization for HF, Circulation; ePub 2018 Sep 13; Ambrosy, et al

FFR and Quality of Life After PCI, Circulation; ePub 2018 Sep 18; Nishi, et al

VTE risk for continuous cycle oral contraceptives, Li J et al. JAMA Intern Med. 2018 Oct 1. doi:10.1001/jamainternmed.2018.4251

Must Reads in Hypercholesterolemia

Racial Differences in Statin Use, JAMA Cardiol; ePub 2018 Jun 13; Nanna, et al

LLT Use in Patients with Elevated LDL-C, Circ Cardiovasc Qual Outcomes; ePub 2018 May 10; Virani, et al

Evolocumab in Differing Patient Populations , J Pharmacokinet Pharmacodyn; ePub 2018 May 7; Kuchimanchi, et al

LDL-C Targets in Elderly Statin Users After ACS, J Am Heart Assoc; ePub 2018 May 12; Alter, et al

Patient Perspectives on Statin Therapy, Clin Cardiol; ePub 2018 May 10; Brinton