More than 50% of children with nonalcoholic fatty liver disease (NAFLD) met intervention thresholds for dyslipidemia, warranting lipid screening in this population group. This according to a multicenter, longitudinal cohort study that included 585 children (mean age 12.8 years) with NAFLD. Fasting lipid profiles were obtained at diagnosis. After 1 year, lipid profiles were repeated and interpreted according to National Heart, Ling, and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction. Main outcomes were meeting criteria for clinically actionable dyslipidemia at baseline, and either achieving lipid goal at follow-up or meeting criteria for ongoing intervention. Researchers found:
- The prevalence of children warranting intervention for low-density lipoprotein cholesterol (LDL-C) at baseline was 14%.
- After 1 year of recommended dietary changes, 51% achieved goal LDL-C, 27% qualified for enhanced dietary and lifestyle modifications, and 22% met criteria for pharmacologic intervention.
- Elevated triglycerides were more prevalent, with 51% meeting criteria for intervention.
Harlow KE, Africa JA, Wells A, et al. Clinically actionable hypercholesterolemia and hypertriglyceridemia in children with nonalcoholic fatty liver disease. [Published online ahead of print April 13, 2018]. J Pediatr. doi:10.1016/j.jpeds.2018.02.038.
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CAD Severity as a Function of Patient Sex, Am Heart J; ePub 2018 Oct 2; Pagidipati, et al
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Racial Differences in Statin Use, JAMA Cardiol; ePub 2018 Jun 13; Nanna, et al
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Evolocumab in Differing Patient Populations , J Pharmacokinet Pharmacodyn; ePub 2018 May 7; Kuchimanchi, et al
LDL-C Targets in Elderly Statin Users After ACS, J Am Heart Assoc; ePub 2018 May 12; Alter, et al
Patient Perspectives on Statin Therapy, Clin Cardiol; ePub 2018 May 10; Brinton