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FH and High LDL-C in Risk of Ischemic Stroke

Circulation; ePub 2018 Mar 28; Beheshti, et al

Familial hypercholesterolemia (FH) and high concentrations of low-density lipoprotein cholesterol (LDL-C) did not confer an increased risk of ischemic stroke, a recent study found. The associations of FH and high LDL-C with ischemic stroke risk were tested in causal, genetic, and observational analyses using 106,412 individuals from the Copenhagen General Population Study (CGPS) and/or 10,372 individuals from the Copenhagen City heart study (CCHS). Researchers found:

  • The cumulative incidences in individuals in the CGPS with and without FH causative mutations were similar for ischemic stroke, but not for myocardial infarction (MI); results were similar in the CCHS.
  • There was no association between clinical FH and ischemic stroke, expect if personal premature ischemic heart disease was included in the clinical FH criteria.
  • Ischemic heart disease at baseline was associated with higher ischemic stroke risk.
  • For a 1 mmol/L higher LDL-C, the genetic causal risk ratio was 1.11 for ischemic stroke and 1.45 for MI.

Citation:

Beheshti S, Madsen CM, Varbo A, Benn M, Nordestgaard BG. Relationship of familial hypercholesterolemia and high LDL cholesterol to ischemic stroke: The Copenhagen General Population Study. [Published online ahead of print March 28, 2018]. Circulation. doi:10.1161/CIRCULATIONAHA.118.033470.

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