Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Dual Lipid-Lowering Therapy Better?

Atherosclerosis; 2018 Feb; Gragnano, et al

Dual-lipid-lowering therapy (DULT) is more effective than statin monotherapy in high-risk patients with coronary artery disease (CAD), according to a recent review. The review determined that in recent trials, combination strategies involving a statin and non-statin agent have been shown to promote coronary atherosclerosis regression and improve cardiovascular (CV) outcomes in patients with moderate-to-high CV risk. The authors concluded:

  • DULT should be implemented in patients above the recommended low-density lipoprotein cholesterol (LDL-C) target on a high-intensity statin and might be proposed as a first-line strategy in certain patients regardless of their LDL-C levels.
  • Preference for 1 of the 2 strategies (NPC1L1 blockade or PCSK9 inhibition) should be evaluated case by case, according to the patient’s characteristics, LDL-C levels, risk profile, and national regulatory agency indications.


Gragnano F, Calabró P. Role of dual lipid-lowering therapy in coronary atherosclerosis regression: Evidence from recent studies. Atherosclerosis. 2018;269:219-228. doi:10.1016/j.atherosclerosis.2018.01.012.

This Week's Must Reads

Detection & Management of Resistant Hypertension, Hypertension; ePub 2018 Sep 13; Carey, et al

Does Aspirin Prevent CV Events in Older Adults?, N Engl J Med; ePub 2018 Sep 16; McNeil, et al

Timing of ICD Placement From Last Hospitalization for HF, Circulation; ePub 2018 Sep 13; Ambrosy, et al

FFR and Quality of Life After PCI, Circulation; ePub 2018 Sep 18; Nishi, et al

VTE risk for continuous cycle oral contraceptives, Li J et al. JAMA Intern Med. 2018 Oct 1. doi:10.1001/jamainternmed.2018.4251

Must Reads in Hypercholesterolemia

Racial Differences in Statin Use, JAMA Cardiol; ePub 2018 Jun 13; Nanna, et al

LLT Use in Patients with Elevated LDL-C, Circ Cardiovasc Qual Outcomes; ePub 2018 May 10; Virani, et al

Evolocumab in Differing Patient Populations , J Pharmacokinet Pharmacodyn; ePub 2018 May 7; Kuchimanchi, et al

LDL-C Targets in Elderly Statin Users After ACS, J Am Heart Assoc; ePub 2018 May 12; Alter, et al

Patient Perspectives on Statin Therapy, Clin Cardiol; ePub 2018 May 10; Brinton