Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Bariatric Surgery Improve Lipoprotein Profile?

J Clin Lipidol; ePub 2017 Oct 25; Kjellmo, et al

In morbidly obese patients, bariatric surgery improves lipoprotein profile with favorable effects on triglycerides, low-density lipoprotein cholesterol (LDL-C), and apoB, a recent study found. 34 morbidly obese patients were evaluated before and after lifestyle changes and then 1 year after bariatric surgery. They were compared to 17 lean individuals and several lipoprotein metrics, amyloid A (SAA), serum paraoxonase/arylesterase 1 (PON1), and macrophage cholesterol efflux capacity (CEC), were assessed. Researchers found:

  • Average weight loss after lifestyle intervention was 10.5% and 1 year after bariatric surgery was ~34.0%.
  • The lifestyle intervention significantly decreased triglycerides, LDL-C, and apoB.
  • Bariatric surgery further reduced triglycerides, increased HDL cholesterol, and reductions in LDL-C and apoB were sustained.
  • No changes in macrophage CEC were observed.

Citation:

Kjellmo CA, Karlsson H, Nestvold TK, et al. Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL-cholesterol, apoB and SAA/PON1 ratio, increasing HDL-cholesterol, but has no effect on cholesterol efflux capacity. [Published online ahead of print October 25, 2017]. J Clin Lipidol. doi:10.1016/j.jacl.2017.10.007.

This Week's Must Reads

Lipid Testing After Acute Myocardial Infarction, J Am Heart Assoc; ePub 2018 Jan 25; Wang, et al

Clinical Pharmadynamics of Evolocumab, Clin Pharmacokinet; ePub 2018 Jan 20; Kasichayanula, et al

Lipoproteins & CV Outcomes in Dialysis Patients, J Clin Lipidol; ePub 2017 Dec 26; Kaysen, et al

Is Dual Lipid-Lowering Therapy Better?, Atherosclerosis; 2018 Feb; Gragnano, et al

sLOX-1 in Ischemic Stroke & Transient Ischemic Attack, J Am Heart Assoc; ePub 2018 Jan 12; Skarpengland, et al

Must Reads in Hypercholesterolemia

Lipid Testing After Acute Myocardial Infarction, J Am Heart Assoc; ePub 2018 Jan 25; Wang, et al

Clinical Pharmadynamics of Evolocumab, Clin Pharmacokinet; ePub 2018 Jan 20; Kasichayanula, et al

Lipoproteins & CV Outcomes in Dialysis Patients, J Clin Lipidol; ePub 2017 Dec 26; Kaysen, et al

Is Dual Lipid-Lowering Therapy Better?, Atherosclerosis; 2018 Feb; Gragnano, et al

sLOX-1 in Ischemic Stroke & Transient Ischemic Attack, J Am Heart Assoc; ePub 2018 Jan 12; Skarpengland, et al