Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Clinical Pharmadynamics of Evolocumab

Clin Pharmacokinet; ePub 2018 Jan 20; Kasichayanula, et al

The pharmacodynamic effects of PCSK9 inhibitor evolocumab are rapid, with maximum suppression within 4 hours, according to a recent review of the clinical pharmacokinetics and pharmacodynamics. The review also found:

  • Evolocumab exhibits nonlinear kinetics and a half-life of 11 to 17 days.
  • With maximal suppression of PCSK9 occurring within 4 hours, peak reduction of LDL-C, ranging from 55 to 75%, occurs ~1-2 weeks after a dose of evolocumab.
  • Patient-specific factors do not have a clinically meaningful effect on the pharmacodynamic effects of evolocumab; thus, no dose adjustment is necessary based on patient-specific factors of concomitant medication use.
  • When combined with a statin, evolocumab can result in additional lowering of LDL-C.

Citation:

Kasichayanula S, Grover A, Emery MG, et al. Clinical pharmacokinetics and pharmacodynamics of evolocumab, a PCSK9 inhibitor. [Published online ahead of print January 20, 2018]. Clin Pharmacokinet. doi:10.1007/s40262-017-0620-7.

This Week's Must Reads

Omega-3 Fatty Acids for Prevention of CVD, Cochrane Library; ePub 2018 Jul 18; Abdelhamid, et al

Elevated hs-CRP Among Patients with Prior MI, Am Heart J; ePub 2018 Jul 26; Pagidipati, et al

Catheter Ablation for Ventricular Arrhythmias, Am J Cardiol; ePub 2018 Jul 18; Ogunbayo, et al

PIs and CV Outcomes in Patients with HIV and HF, J Am Coll Cardiol; 2018 Jul; Alvi, Neilan, et al

Hypertension in Blacks Higher Through Middle Age, J Am Heart Assoc; ePub 2018 Jul 11; Thomas, et al

Must Reads in Hypercholesterolemia

Racial Differences in Statin Use, JAMA Cardiol; ePub 2018 Jun 13; Nanna, et al

LLT Use in Patients with Elevated LDL-C, Circ Cardiovasc Qual Outcomes; ePub 2018 May 10; Virani, et al

Evolocumab in Differing Patient Populations , J Pharmacokinet Pharmacodyn; ePub 2018 May 7; Kuchimanchi, et al

LDL-C Targets in Elderly Statin Users After ACS, J Am Heart Assoc; ePub 2018 May 12; Alter, et al

Patient Perspectives on Statin Therapy, Clin Cardiol; ePub 2018 May 10; Brinton