Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Timing of ICD Placement From Last Hospitalization for HF

Circulation; ePub 2018 Sep 13; Ambrosy, et al

Older patients currently or recently hospitalized for heart failure (HF) undergoing initial implantable cardioverter-defibrillator (ICD) placement for primary prevention experienced a higher rate of periprocedural complications and were at increased risk of death compared to those receiving an ICD without recent HF hospitalization, a new study found. The post-hoc analysis grouped patients based on timing of ICD placement from last hospitalization for HF. The association between timing of ICD placement and outcomes was assessed using multivariable logistic regression models. Researchers found:

  • The analytical cohort included 81,180 patients undergoing initial ICD placement for HF within 3 months (n=6,252, 8%), or hospitalized for HF >3 months prior or had no previous hospitalizations for HF (n=63,365, 78%).
  • Patients currently or recently hospitalized for HF had a higher periprocedural complication rate.
  • After adjusting for potential confounders, patients currently hospitalized for HF were at higher risk for death and all-cause readmission at 90 days.


Ambrosy AP, Parzynski CS, Friedman DJ, et al. Is time from last hospitalization for heart failure to placement of a primary prevention implantable cardioverter-defibrillator associated with patient outcomes? [Published online ahead of print September 13, 2018]. Circulation. doi:10.1161/CIRCULATIONAHA.118.035627.

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