Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Updated Guidance on Treating Kawasaki Disease

Circulation; ePub 2017 Mar 29; McCrindle, et al

The American Heart Association (AHA) has issued recommendations and best evidence-based guidance for healthcare providers who diagnose and manage Kawasaki disease (KD), a leading cause of acquired heart disease in children in developed countries. The goal of the scientific statement is to provide updated recommendations for diagnosis, treatment of the acute illness, and long-term management. It incorporates the following:

  • New evidence regarding underlying pathological processes.
  • An algorithm to ensure capture of incomplete KD during the effective window of therapy.
  • Improved management of the acute illness that includes the use of additional therapies for IVIG-refractory patients.
  • Greater use of Z scores for classifying coronary artery involvement.
  • Greater specification of long-term management based on both initial and current coronary artery involvement.
  • Acknowledgement of the care needs of a growing population of adults with a previous history of KD and coronary artery aneurysms.


McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease. A scientific statement from healthcare professionals from the American Heart Association. [Published online ahead of print March 29, 2017]. Circulation. doi:10.1161/CIR.0000000000000484.

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