Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Childhood Adversity & Cardiometabolic Outcomes

Circulation; ePub 2017 Dec 18; Suglia, et al

The American Heart Association (AHA) has issued a scientific statement on adverse experiences in childhood and adolescence, which are known to be associated with cardiometabolic outcomes over the life course into adulthood. The statement reviews scientific literature on the influence of childhood adversity on cardiometabolic outcomes that constitute the greatest public health burden in the US, including obesity, hypertension, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). It also outlines pathways linking adversity to cardiometabolic health, identifies evidence gaps, and provides suggestions for future research. Among the statement’s conclusions:

  • Evidence suggests that childhood adversity is associated with adverse health behaviors that increase risk of cardiometabolic disease, including smoking, overeating, and inactivity.
  • Cardiometabolic health outcomes and adverse experiences are strongly patterned by sex, race/ethnicity, socioeconomic status, and nativity.
  • 3 pathways are identified to explain how childhood adversity may increase risk of cardiometabolic, as well as others, diseases: behavioral, mental health, and biological.
  • Interventions that ameliorate upstream exposures may be more appropriate than remediating downstream CVD risk factor effects later in life.

Citation:

Suglia SF, Koenen KC, Chan PS, et al. Childhood and adolescent adversity and cardiometabolic outcomes. A scientific statement from the American Heart Association. [Published online ahead of print December 18, 2017]. Circulation. doi:10.1161/CIR.0000000000000536.

This Week's Must Reads

Omega-3 Fatty Acids for Prevention of CVD, Cochrane Library; ePub 2018 Jul 18; Abdelhamid, et al

Elevated hs-CRP Among Patients with Prior MI, Am Heart J; ePub 2018 Jul 26; Pagidipati, et al

Catheter Ablation for Ventricular Arrhythmias, Am J Cardiol; ePub 2018 Jul 18; Ogunbayo, et al

PIs and CV Outcomes in Patients with HIV and HF, J Am Coll Cardiol; 2018 Jul; Alvi, Neilan, et al

Hypertension in Blacks Higher Through Middle Age, J Am Heart Assoc; ePub 2018 Jul 11; Thomas, et al

Must Reads in Clinical Guidelines

2017 ACC/AHA BP Guideline Impact on Stroke Survivors, J Am Heart Assoc; ePub 2018 Jun 6; Lekoubou, et al

Comparing Hypertension Guidelines in CV Events, JAMA Cardiol; ePub 2018 May 23; Bundy, et al

AHA: Management of Right-Sided Heart Failure, Circulation; ePub 2018 Apr 12; Konstam, et al

AHA Statement on Promotion of Physical Activity, Circulation; ePub 2018 Apr 4; Lobelo, et al

AHA Statement on CVD & Breast Cancer, Circulation; ePub 2018 Feb 1; Mehta, et al