Compared with anthracyclines, treatment with novel targeted chemotherapeutic agents (TCAs) was associated with a significantly reduced risk of new-onset arrhythmia diagnosis during the first 6 months of treatment, according to a recent study. 5,026 patients were identified, of whom 2,951 (58.7%) received TCAs and 2,075 (41.3%) received anthracycline chemotherapy. Cancer treatment-induced arrhythmia (CTIA) was defined as any new arrhythmia diagnosis code within 6 months after treatment initiation. Researchers found:
- In the overall cohort, 601 (12.0%) patients developed CTIA.
- Patients with CTIA were significantly older and more likely to have hypertension, diabetes mellitus, congestive heart failure, coronary disease, and sleep apnea.
- The incidence of CTIA at 6 months was significantly lower in the TCA group (9.3% vs 15.8%).
- In a multivariate analysis, treatment with TCAs compared with anthracycline chemotherapy was associated with a significantly lower risk of CTIA (HR, 0.60).
Nickel AC, Patel A, Saba NF, Leon AR, El-Chami MF, Merchant FM. Incidence of cancer treatment-induced arrhythmia associated with novel targeted chemotherapeutic agents. [Published online ahead of print October 13, 2018]. J Am Heart Assoc. doi:10.1161/JAHA.118.010101.
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Evolocumab Lowers LDL-C in Patient Subgroups, Clin Cardiol; 2018 Oct 21; Stroes, Robinson, et al
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Must Reads in Arrhythmias & EP
Cancer Treatment-Induced Arrhythmia with TCAs, J Am Heart Assoc; ePub 2018 Oct 13; Nickel, et al
Effect of AF on Outcomes in Women Undergoing TAVI, Am J Cardiol; ePub 2018 Sep 7; Guedeney, et al
Psychosocial Stressors & AF in Older Women, Am J Cardiol; ePub 2018 Aug 17; Westcott, et al
Dementia Progression in Men and Women with AF, Am J Cardiol; ePub 2018 Aug 3; Golive, et al
SSRIs & Bleeding Risk in AF Patients Taking Anticoagulants, J Am Heart Assoc; ePub 2018 Jul 27; Quinn, et al