Following an acute coronary syndrome (ACS), patients with peripheral artery disease (PAD) have a significantly higher risk of first and recurrent ischemic events compared to those without PAD, a recent study found. Researchers analyzed the combined dataset from 4 randomized trials in ACS for a follow-up length of 1 year and examined the association between PAD and major adverse cardiovascular events (MACE), a composite of CV death, myocardial infarction (MI), and stroke. They found:
- A total of 4,098 of 48,094 (8.5%) post-ACS patients had a history of PAD.
- The unadjusted frequency of MACE was 2-fold higher in patients with PAD over a median follow-up of 353 days with an adjusted hazard ratio of 1.63.
- The frequency of recurrent ischemic events among patients with a first, non-fatal event was higher among those with PAD.
- Relative frequency of each event type within first and subsequent ischemic events was similar regardless of PAD status at baseline.
Inohara T, Pieper K, Wojdyla DM, et al. Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. [Published online ahead of print March 28, 2018]. Am Heart J. doi:10.1016/j.ahj.2018.03.013.
This Week's Must Reads
Detection & Management of Resistant Hypertension, Hypertension; ePub 2018 Sep 13; Carey, et al
Does Aspirin Prevent CV Events in Older Adults?, N Engl J Med; ePub 2018 Sep 16; McNeil, et al
Timing of ICD Placement From Last Hospitalization for HF, Circulation; ePub 2018 Sep 13; Ambrosy, et al
FFR and Quality of Life After PCI, Circulation; ePub 2018 Sep 18; Nishi, et al
VTE risk for continuous cycle oral contraceptives, Li J et al. JAMA Intern Med. 2018 Oct 1. doi:10.1001/jamainternmed.2018.4251
Must Reads in Acute Coronary Syndromes
Barriers to Healthcare Access After an ACS, Am J Cardiol; ePub 2018 Jul 15; Erskine, et al
LOS After Non-ST-Segment Elevation Acute MI, Am Heart J; ePub 2018 Apr 19; Rymer, et al
Ischemic Events in Patients with PAD After an ACS, Am Heart J; ePub 2018 Mar 28; Inohara, et al
Outcomes in Patients with ACS Due to LMCAD , Am Heart J; ePub 2018 Feb 22; Gharacholou, et al
Adherence Rates to Secondary Prevention Meds, Circulation; ePub 2018 Jan 31; Mathews, et al