Clinical Edge

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Seborrheic Keratosis and Cutaneous Horn of Eyelid

Ophthal Plast Reconstr Surg; 2017 Jul; Pointdujour-Lim, et al

The clinical significance of cutaneous horn of the eyelid lies not in the horn itself but the nature of the underlying base, according to a recent study that found malignancy in 23% of patients. A retrospective analysis of 13 cases of cutaneous horn of the eyelid treated between 1994 and 2014 was performed. The mean patient age was 54 years (median 64 years, range 9–91 years), and 6 patients (46%) were women. Researchers found:

  • The tumor base included benign (n=6, 46%), premalignant (n=4, 31%), and malignant (n=3, 23%) conditions.
  • The benign basal lesions included seborrheic keratosis (n=1), nevus sebaceous of Jadassohn (n=1), pseudoepitheliomatous hyperplasia (n=1), trichilemmoma (n=1), and inverted follicular keratosis (n=2).
  • Premalignant basal lesions were actinic keratosis (n=4), and malignant basal lesions included squamous cell carcinoma (n=2) and sebaceous gland carcinoma (n=1).


Pointdujour-Lim R, Marous MR, Satija CE, et al. Cutaneous horn of the eyelid in 13 cases. Ophthal Plast Reconstr Surg. 2017;33(4):233-235. doi:10.1097/IOP.0000000000000816.