Pemphigoid—an autoimmune disorder that causes skin rashes and blistering on the legs, arms, and abdomen—is rare in the US, according to a recent study. Patients aged ≥60 years comprise the majority of cases. Researchers conducted a cross-sectional analysis using electronic health records data for a demographically heterogeneous population-based sample of >55 million patients across all 4 census regions. They found:
- Overall pemphigoid prevalence was 0.012%, or 12 pemphigoid patients per 100,000.
- Prevalence of pemphigoid among those aged >60 years was 0.038%, or 37.7 per 100,000.
- Prevalence increased approximately 2-fold within each successive age group and was highest among patients aged >90 years (123.6 per 100,000).
- Adjusted prevalence in women was 12.7 per 100,000, slightly more than that of men (11.0 per 100,000).
- Adjusted prevalence was similar for African Americans (15.4 per 100,000) and Caucasians (13.5 per 100,000).
Wertenteil S, Garg A, Strunk A, Alloo A. Prevalence estimates for pemphigoid in the United States: A gender and age adjusted population analysis. [Published online ahead of print August 27, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.08.030.