Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Treatment Patterns Among Patients with Psoriasis

J Med Econ; ePub 2018 Oct 25; Murage, et al

While the majority of patients with psoriasis initiated a pharmacological therapy, a significant portion did not have a claim for any psoriasis medication, a recent study found. Topical treatments are the most commonly used treatments for psoriasis. Non-biologic systemic and biologic therapies were rarely used first line, but became more common in later lines of treatment. Adult patients with newly-diagnosed psoriasis had continuous enrollment with medical and pharmacy benefits for ≥6 months prior to and ≥1 year following the index date, the point at which specific inclusion criteria were satisfied. Researchers found:

  • From 128,308 patients identified, 53% were female, mean ± SD age was 50 ± 16 years, with median 3-year follow-up.
  • Topicals were received by 86% of patients, non-biologic systemics by 13%, biologics by 6%, phototherapy by 5%, and 13% received no psoriasis-related medication.
  • Median time from index to first treatment was 0 days for topical, 6 months for non-biologic systemic, and 6 months for biologic.
  • Of those treated, first-line therapies included topical (95%), non-biologic systemic (4%), and biologic (2%).
  • For those with second-line treatment, non-biologic systemic (71%) and biologic (30%) therapies were more common.


Murage MJ, Kern DM, Chang L, et al. Treatment patterns among patients with psoriasis using a large national payer database in the United States: A retrospective study. [Published online ahead of print October 25, 2018]. J Med Econ. doi:10.1080/13696998.2018.1540424.