Therapeutic choices for psoriasis impact mental health outcomes, according to a recent study, which determined that biologic therapy is associated with reductions in psychological distress and depression as compared to oral therapy in the US adult moderate-to-severe psoriasis population. Researchers performed a nationwide, cross-sectional study comparing 2,303,534 (weighted) adults with moderate-to-severe psoriasis on biologic vs oral therapies and their associated mental health outcomes using the 2003-2015 Medical Expenditure Panel Survey (MEPS). Mental health outcomes were measured with the Kessler 6 (K6), a validated measure of psychological distress, and Patient Health Questionnaire 2 (PHQ2), a screening tool for depression. They found:
- The mean K6 score for residents on biologic therapies was significantly lower than that of residents on oral therapies (2.72 vs 3.70).
- The mean PHQ2 score for residents on biologic therapies was also significantly lower than that of residents on oral therapies (0.540 vs 0.890).
- Based on adjusted multivariable linear regression models, biologic therapy was associated with significant reductions in K6 and PHQ2 scores compared to oral therapy.
Salame N, Ehsani-Chimeh N, Armstrong AW. Comparison of mental health outcomes among adults with psoriasis on biologic versus oral therapies: A population-based study. [Published online ahead of print May 14, 2018]. J Dermatolog Treat. doi:10.1080/09546634.2018.1476654
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