Appropriate medical screening for possible cardiovascular comorbidities is warranted in Asian patients with psoriasis according to disease severity and gender, a new study found. The nationwide population-based cohort study included >1.7 million Koreans with a 15-year follow-up period. The period prevalence of psoriasis was 0.33% among baseline participants. Among the findings:
- In Cox proportional hazard analyses, individuals with psoriasis had a higher adjusted hazard ratio (HR) for incidence of overall atherosclerotic cardiovascular disease (CVD) (HR 1.18) compared with controls.
- Subgroup analyses revealed that the risk for myocardial infarction was commonly increased in both sexes with moderate to severe psoriasis (male: HR 2.09; female: HR 3.23), whereas the risk of ischemic stroke was specifically increased in female individuals with moderate to severe psoriasis (HR 2.02).
Jung KJ, et al. Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study. [Published online ahead of print August 20, 2019]. J Dermatol. doi: 10.1111/1346-8138.15052.