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Psoriasis, PsA Associated with Liver Disease

J Invest Dermatol; ePub 2017 Nov 2; Ogdie, et al

More so than rheumatoid arthritis (RA), psoriasis (PsO) and psoriatic arthritis (PsA) are associated with liver disease, particularly non-alcoholic fatty liver disease (NAFLD) and cirrhosis, and this was true even among patients without systemic therapy (ST) exposure, according to a recent study. Researchers performed a cohort study among patients with PsO, PsA, or RA and matched controls in The Health Improvement Network from 1994-2014. Outcomes of interest were any liver disease, NAFLD, and cirrhosis (any etiology). They found:

  • Among patients with psoriasis (n=197,130), PsA (n=12,308), RA (n=54,251), and matched controls (n=1,279,754), the adjusted hazard ratios for any liver disease were elevated among patients with PsO, PsA, and RA without a ST but not elevated in RA patients prescribed a ST.
  • Incident NAFLD was highest in patients with PsO prescribed a ST and PsA with a ST.
  • Risk of cirrhosis was highest among patients with PsO with a ST and PsA without a ST.
  • Additionally, the prevalence of liver disease and cirrhosis increased in a stepwise fashion with increasing body surface area affected by PsO.

Citation:

Ogdie A, Grewal SK, Noe MH, et al. Risk of incident liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis: A population-based study. [Published online ahead of print November 2, 2017]. J Invest Dermatol. doi:10.1016/j.jid.2017.10.024.