By using 147 RNA samples, researchers recently discovered a striking correlation between dysregulated genes in lesional psoriasis and lesional atopic dermatitis (AD) skin, with 81% of AD dysregulated genes being shared with psoriasis. They conducted a large-scale transcriptomic study of AD with deeply sequenced RNA-sequencing samples using long (126-bp) paired-end reads. In addition to the comparisons against previous transcriptomic studies, they conducted in-depth analysis to obtain a high-resolution view of the global architecture of the AD transcriptome and contrasted it with that of psoriasis from the same cohort. AD and psoriasis transcriptomes were compared using RNA sequencing and demonstrated the shared inflammatory components, as well as specific discordant cytokine signatures, of these 2 skin diseases.
Tsoi LC, Rodriguez E, Degenhardt F. Atopic dermatitis is an IL-13–dominant disease with greater molecular heterogeneity compared to psoriasis. [Published online ahead of print January 11, 2019]. J Invest Dermatol. doi:10.1016/j.jid.2018.12.018.