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Physical and Mental Functioning in Psoriasis Treatment

Among US adult patients with moderate-to-severe psoriasis, biologic therapy is associated with significantly greater increases in measures of physical and mental functioning compared to oral therapy, a new study found. Researchers performed a nationwide, cross-sectional study of 2,431,282 US adults with psoriasis on biologic or oral therapy using the 2013-2015 Medical Expenditure Panel Survey. They found:

  • The mean Physical Component Summary (PCS) scored among patients on biologic therapy was significantly higher vs patients on oral therapy.
  • The mean Mental Component Summary (MCS) score among patients on biologic therapy was also significantly higher than that of patients on oral therapy.
  • Biologic therapy was associated with a significantly greater increase in measures of physical functioning and mental functioning as compared to oral therapy.


Salame N, Ehsani-Chimeh N, Armstrong AW. Comparison of physical and mental functioning among moderate-to-severe psoriasis patients on biologic versus oral therapy. [Published online ahead of print April 24, 2019]. Arch Dermatol Res. doi:10.1007/s00403-019-01918-9.