Metabolic syndrome was associated with increased risk of incident psoriasis, according to a recent study and results suggest that this positive association could, at least partly, be attributed to adiposity. Researchers used data from 2 consecutive surveys of the HUNT Study (HUNT2, 1995–1997, and HUNT3, 2006–2008). 34,996 women and men aged ≥20 years without psoriasis in HUNT2 were followed up in HUNT3, and 374 incident cases of psoriasis were identified. They found:
- Metabolic syndrome was associated with a relative risk (RR) for psoriasis of 1.66.
- To explore the influence of adiposity on this association, waist circumference was first excluded from the definition of metabolic syndrome (adjusted RR 1.54) and then adjusted for body mass index (BMI) (RR 1.33).
- Analyses of the separate components of metabolic syndrome showed positive associations with risk of psoriasis for waist circumference, triglycerides, and high‐density lipoprotein (HDL) cholesterol, but not for blood pressure or blood glucose.
- There was also an increased risk of psoriasis for high total cholesterol.
- The increased risk associated with high triglycerides, HDL cholesterol, and total cholesterol was attenuated after adjusting for BMI.
Snekvik I, Nilsen TIL, Romundstad PR, Saunes M. Metabolic syndrome and risk of incident psoriasis: Prospective data from the HUNT Study, Norway. Br J Dermatol. 2019;180(10):94-99. doi:10.1111/bjd.16885.