Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Immune Mediated Inflammatory Diseases in Psoriasis

Immune-mediated inflammatory diseases (IMIDs) frequently occur in patients with psoriasis and most are diagnosed before psoriasis, a new study found. Researchers utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). They found:

  • 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population.
  • Most IMIDs occurred prior to the diagnosis of psoriasis, accept for psoriatic arthritis.
  • Psoriasis was significantly associated with having multiple IMIDs.


Andersen YMF, Wu J, Thyssen JP, Egeberg A. Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis. [Published online ahead of print April 19, 2019]. J Am Acad Dermatol. doi:10.1016/j.jaad.2019.04.033.