Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Sodium Bicarbonate Relieve Psoriatic Lesions?

In a controlled study of patients with mild-to-moderate stable plaque psoriasis, the use of a topical formulation of sodium bicarbonate (SB) did not improve psoriatic lesions. The study aimed to determine the effectiveness of a galenic SB in lanette vax formulation compared with lanette vax base. The randomized, double-blind, controlled study was performed in 28 days. Among the findings:

  • 30 patients of both genders were selected for testing.
  • Data analysis of objective parameters highlighted that use of the SB topical preparation led to no improvement in skin hydration, no reduction in transepidermal water loss, and no decrease or erythema.
  • The modified Psoriasis Area and Severity Index (PASI) and body surface area (BSA) did not change from baseline.


Mazzarello V, Piu G, Ferrari M, Piga G. Efficacy of a topical formulation of sodium bicarbonate in mild to moderate stable plaque psoriasis: A randomized, blinded, intrapatient, controlled study. [Published online ahead of print May 10, 2019]. Dermatol Ther (Heidelb). doi: 10.1007/s13555-019-0302-5.