Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Vermilion vs Cutaneous Location in cSCC of the Lip

JAMA Dermatology; ePub 2018 May 2; Wang, et al

The risk of nodal metastasis is 5-fold greater for cutaneous squamous cell carcinomas (cSCCs) on the vermilion lip compared with those on the cutaneous lip, according to a recent study. Furthermore, SCCs of the cutaneous lip have a nodal metastasis risk similar to cSCCs in general (1.5%). Researchers conducted a retrospective cohort study of 303 patients with 310 primary cSCCs of the lip (138 cutaneous, 172 vermilion) diagnosed between 2000 and 2015 at 2 academic tertiary care centers in Boston, MA. They found:

  • Of the total study participants with SCCs of the lip, 153 (50.5%) were men, and 150 (49.5%) were women; median age at diagnosis was 68 years (range, 27-93 years).
  • Outcomes were as follows for vermilion vs cutaneous locations: local recurrence, 6.4% (11 of 172) vs 2.9% (4 of 138); nodal metastasis, 7.6% (13 of 172) vs 1.5% (2 of 138); distant metastasis, 0.6% (1 of 172) vs 0.7% (1 of 138); disease-specific death, 3.5% (6 of 172) vs 2.9% (4 of 138); and all-cause death, 26.7% (46 of 172) vs 29.0% (40 of 138).
  • The difference was statistically significant for nodal metastasis.


Wang DM, Kraft S, Rohani P, et al. Association of nodal metastasis and mortality with vermilion vs cutaneous lip location in cutaneous squamous cell carcinoma of the lip. [Published online ahead of print May 2, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.0792.

This Week's Must Reads

Racial Differences in Psoriasis Therapy Perceptions, J Invest Dermatol; ePub 2019 Feb 6; Takeshita, et al

Detecting Atherosclerotic Plaques in Psoriasis, PLoS One; ePub 2019 Feb 8; Gonzalez-Cantero, et al

Smoking, Not Alcohol, Linked with Psoriasis Risk, J Am Acad Dermatol; 2019 Mar; Dai, et al

Maternal Socioeconomic Position, Psoriasis Linked, Br J Dermatol; 2019 Feb; Groot, Nybo Andersen, et al

Psoriasis: A “Protective Effect” Against Allergens?, Br J Dermatol; 2019 Feb; Claßen, et al

Must Reads in Nonmelanoma Skin Cancer

HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al

Health Care Screening, Skin Cancer Risk Link Found, JAMA Dermatology; ePub 2018 Dec 26; Drucker, et al

Factors Associated with Suspected Skin Cancers , J Am Acad Dermatol; ePub 2018 Dec 10; Beaulieu, et al

Cutaneous Pleomorphic Sarcoma Prognosis Examined, J Am Acad Dermatol; ePub 2018 Nov 8; Ibanez, et al

High Risk SCC and Mohs Micrographic Surgery, J Am Acad Dermatol; ePub 2018 Sep 19; Marrazzo, et al