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Advanced basal cell carcinoma responds to pembrolizumab in single-investigator study

Key clinical point: The progressive death 1 inhibitor pembrolizumab, given with or without vismodegib, resulted in robust response rates in some patients with advanced basal cell carcinoma.

Major finding: The overall response rate was 38%, or 6 of 16 patients, with a 70% probability of 1-year progression-free survival and 94% probability of 1-year overall survival.

Study details: A nonrandomized, investigator-initiated study including 16 patients with advanced basal cell carcinoma.

Disclosures: Funding for the study was provided by Merck. Dr. Chang reported serving as a clinical investigator and advisory board member for studies sponsored by Genentech-Roche, Merck, Novartis, and Regeneron.

Citation:

REPORTING FROM WCD2019