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Pyoderma Gangrenosum Comorbidities and Patient Age

JAMA Dermatology; ePub 2018 Feb 14; Ashchyan, et al

In a clinical presentation in a recent large cohort study examining comorbidities associated with pyoderma gangrenosum (PG), researchers found that disease associations varied by age. Therefore, these findings may allow for a more focused, age-specific evaluation of patients with PG. This study, performed at tertiary academic referral centers in urban settings, included adults (aged ≥18 years) who were evaluated and diagnosed as having PG. They found:

  • Of the 356 validated cases of PG included in the study, 267 (75%) were women and 284 (84.8%) were white; mean (SD) age at presentation was 51.6 (17.7) years.
  • Pathergy was recorded in 100 patients (28.1%).
  • A total of 161 patients (66.3%) had associated medical comorbidities, the most common being inflammatory bowel disease in 146 patients (41.0%); inflammatory arthritis in 73 patients (20.5%); and solid organ malignant neoplasms in 23 patients (6.5%).
  • When stratified by age, pathergy was more common in patients aged ≥65 years (36.3% vs 24.3%).
  • Inflammatory bowel disease was the only medical comorbidity that was more common in patients aged <65 years (47.7% vs 26.6%).


Ashchyan HJ, Butler DC, Nelson CA, et al. The association of age with clinical presentation and comorbidities of pyoderma gangrenosum. [Published online ahead of print February 14, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2017.5978.