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Psoriasis, Nonalcoholic Fatty Liver Disease Linked

J Clin Asthet Dermatol; 2018 Jun 1; Awosika, et al

There is an association of psoriasis with nonalcoholic fatty liver disease (NAFLD), according to a recent study, and findings also suggest an increased presence of metabolic syndrome components in patients with psoriasis and NAFLD. In an observational, case-control study at an outpatient dermatology clinic of the George Washington Medical Faculty Associates in Washington, DC, researchers recruited 151 adult patients with psoriasis and 51 control subjects. NAFLD was diagnosed by ultrasonography after excluding secondary causes of liver disease. Regression analysis was used to assess the associations between: 1) NAFLD and psoriasis and 2) metabolic syndrome components and NAFLD among psoriasis patients. They found:

  • NAFLD was more prevalent in patients with psoriasis (21.2% vs 7.8%).
  • However, psoriasis was not associated with NAFLD when matching for age, sex, and body mass index (BMI) (odds ratio: 2.63).
  • As compared to patients with psoriasis but without NAFLD, those with NAFLD were more likely to have obesity (BMI: 34.9 vs 27.2 vs 25.9–28.5).
  • NAFLD in patients with psoriasis was also associated with select components of metabolic syndrome, including hyperglycemia and hyperlipidemia.

Citation:

Awosika O, Eleryan MG. Rengifo-Pardo M, Doherty L, Martin LW, Ehrlich A. A case-control study to evaluate the prevalence of nonalcoholic fatty liver disease among patients with moderate-to-severe psoriasis. J Clin Aesthet Dermatol. 2018;11(6):33-37.