Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Predicting Disease Activity and Improvement in CLE

J Am Acad Dermatol; ePub 2018 Jul 2; Ker, Teske, et al

Baseline Cutaneous Lupus Erythematosus Disease Area and Severity Index activity (CLASI-A) >9, minority race, and shorter disease duration predict cutaneous lupus erythematosus (CLE) disease activity improvement. This according to a recent study in which researchers characterized and compared the disease course of CLE patients using CLASI. 83 patients with CLASI scores collected from ≥3 study visits within 2 years had disease activity and damage trends calculated by average change scores (ACS). Trends were classified as “improved” (ACS ≤-3), “worsened” (ACS ≥+3), or “stable” (-3< ACS<+3). Linear regression models compared CLASI trends between groups. They found:

  • 72.73% with initial CLASI activity (CLASI-A) >9 (n=33) had improved disease activity vs 14.00% with initial CLASI-A ≤9 (n=50).
  • Linear regression analyses showed significant improvement in CLASI-A scores in patients with baseline CLASI-A >9, baseline CLASI damage (CLASI-D) ≥10, minority races, and CLE disease duration ≤1 year.
  • 35.71% with baseline CLASI-D ≥10 (n=28) had improving disease damage vs 5.26% with initial CLASI-D=5-9 (n=19) and 0% with initial CLASI-D <5 (n=36).

Citation:

Ker KJ, Teske NM, Feng R, Chong BF, Werth VP. Natural history of disease activity and damage in patients with cutaneous lupus erythematosus. [Published online ahead of print July 2, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.06.040.

This Week's Must Reads

Dietary Changes: No Major Effect on Psoriasis, Dermatol Online J; 2019 Feb 15; Pona, et al

Influenza Vaccine Rates in Adults with Psoriasis, J Invest Dermatol; 2019 Feb; Noe, Shin, et al

Psoriasis and AD Share Inflammatory Components, J Invest Dermatol; ePub 2019 Jan 11; Tsoi, et al

Quality of Life Among Patients with Psoriasis, PsA, Arch Dermatol Res; ePub 2019 Mar 13; Duvetorp, et al

Psoriasis and Cardiometabolic Comorbidity in Women, Acta Derm Venereol; 2019 Mar 1; Blegvad, et al

Must Reads in Mixed Topics

Link Found Between AD, Depression, Suicidal Ideation , J Am Acad Dermatol; 2019 Feb; Patel, et al

Patients with Persistent Post-Chemotherapy Alopecia, JAMA Dermatol; ePub 2019 Mar 6; Freites-Martinez, et al

Patients with HS Have Pyoderma Gangrenosum Risk, J Am Acad Dermatol; ePub 2019 Feb 6; Tannenbaum, et al

Telangiectases Location and Distribution in Youth, J Am Acad Dermatol; ePub 2019 Feb 25; Gonzalez, et al

HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al