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Patients with HS Have Pyoderma Gangrenosum Risk

J Am Acad Dermatol; ePub 2019 Feb 6; Tannenbaum, et al

Patients with hidradenitis suppurativa (HS) have increased prevalence of pyoderma gangrenosum (PG), regardless of Crohn’s disease (CD) status, according to a recent study. Therefore, painful ulcerations among HS patients warrant additional evaluation for PG. Researchers conducted a cross-sectional analysis of adults with PG among HS and non-HS patients using electronic health records data from a population-based sample of 55 million patients. They found:

  • Prevalence of PG among 68,232 HS patients was 0.18% (125/68,232), compared to 0.01% (1,835/31,435,166) among those without HS.
  • Prevalence was markedly higher among HS patients having CD (3.68%), compared to HS patients without CD (0.12%).
  • Odds of having PG was 21.14 times greater among HS patients compared to patients without HS.
  • HS patients with CD had 12.38 times the odds of having PG compared to non-HS patients with CD.
  • Among patients without CD, those with HS had 26.51 times the odds of having PG compared to non-HS patients.


Tannenbaum R, Strunk A, Garg A. Overall and subgroup prevalence of pyoderma gangrenosum among patients with hidradenitis suppurativa: A population based analysis in the United States. [Published online ahead of print February 6, 2019]. J Am Acad Dermatol. doi:10.1016/j.jaad.2019.02.004.