Cutaneous marginal zone lymphoma and cutaneous follicle center lymphoma (CMZL/CFCL) in a series of African American (AA) patients had an earlier age of onset with preferential head and neck involvement, a recent study found. Despite these features, systemic involvement was uncommon, and no deaths were recorded. This data supports an indolent course of CMZL and CFCL in the AA population. Researchers conducted a retrospective chart review and compared demographics, clinical features, and systemic disease incidence between AA and white patients. They found:
- Of 288 patients with CMZL/CFCL, 10 patients were AA (3.5%), and 266 were white.
- AA patients trended toward diagnosis at a younger age compared to white individuals (median age of 41 vs 54 years).
- AAs presented with more regional and generalized cutaneous disease (T2-T3 in 70%), while most white patients presented with a solitary lesion (T1 in 55%).
- Head and neck involvement was more common in AA patients.
- Extracutaneous systemic disease at initial staging was not significantly different between the groups.
Geller S, Pulitzer M, Myskowski PL, Kheterpal M. Low-grade cutaneous B-cell lymphoma in African American patients. J Drugs Dermatol. 2018;17(12):1334.
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