Results of a recent study highlight the burden of depression in patients with vitiligo and support the possible existence of pathophysiological connections between these 2 conditions. Researchers sought to evaluate a bidirectional relationship between major depressive disorder (MDD) and vitiligo using The Health Improvement Network (THIN) database. Incident MDD and referent cohorts were followed until the development of vitiligo. Additionally, incident vitiligo and referent cohorts were followed until the development of MDD. They found:
- In adjusted models, MDD patients (n=405,397) were at a 64% increased risk of vitiligo (HR=1.64) compared to the referent cohort (n=5,739,048).
- This risk was decreased in patients using antidepressants.
- Compared to the referent cohort (n=6,137,696), patients with vitiligo (n=7,104) that were aged <30 years at diagnosis had a higher risk of developing MDD than patients aged >30 years (HR=1.31 vs HR=1.22).
Vallerand IA, Lewinson RT, Parsons LM, et al. Vitiligo and major depressive disorder: A bidirectional population-based cohort study. [Published online ahead of print December 5, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.11.047.
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