Stage and anatomic site, but not thickness (ie, Breslow depth), race, or ethnicity, determine prognosis of mucosal melanomas, a recent study found. Therefore, considering the poor prognosis for all stages of mucosal melanoma, dermatologists should incorporate examination of the oropharynx and genitalia in the full body skin exam. Researchers analyzed 132,751 cases of melanoma, including 1,824 mucosal melanomas, diagnosed between 1994 and 2015 and reported to the California Cancer Registry. Kaplan-Meier survival analysis and Cox proportional hazards regression assessed the prognostic variables. They found:
- The 5-year relative survival for mucosal melanomas (27.64%) was significantly lower than for cutaneous melanomas (76.28%).
- Stage independently influenced survival, and thickness did not predict survival for neoplasms of known depth.
- Less common anatomic sites conferred worse prognoses (hazard ratio [HR] 1.93).
Altieri L, Eguchi M, Peng DH, Cockburn M. Predictors of mucosal melanoma survival in a population-based setting. [Published online ahead of print October 5, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.09.054.
This Week's Must Reads
Racial Differences in Psoriasis Therapy Perceptions, J Invest Dermatol; ePub 2019 Feb 6; Takeshita, et al
Detecting Atherosclerotic Plaques in Psoriasis, PLoS One; ePub 2019 Feb 8; Gonzalez-Cantero, et al
Smoking, Not Alcohol, Linked with Psoriasis Risk, J Am Acad Dermatol; 2019 Mar; Dai, et al
Maternal Socioeconomic Position, Psoriasis Linked, Br J Dermatol; 2019 Feb; Groot, Nybo Andersen, et al
Psoriasis: A “Protective Effect” Against Allergens?, Br J Dermatol; 2019 Feb; Claßen, et al
Must Reads in Melanoma
HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al
Poor Prognosis for Thin Ulcerated Melanomas Found, J Am Acad Dermatol; ePub 2019 Jan 14; Hawkins, et al
Cutaneous Nevi and Risk of Melanoma Examined, J Am Acad Dermatol; ePub 2019 Jan 10; Li, et al
Health Care Screening, Skin Cancer Risk Link Found, JAMA Dermatology; ePub 2018 Dec 26; Drucker, et al
Mohs Surgery Beneficial for Melanoma of Head/Neck, Dermatolog Surg; ePub 2018 Dec 13; Demer, et al