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Incidence of Melanoma, Survival Investigated

J Invest Dermatol; ePub 2018 Jul 19; Nosrati, et al

The incidence of melanoma and survival of patients with the disease have increased over the last several decades, with a growing population of patients who develop multiple primary melanomas (MPM), according to a recent investigation. To determine risk factors for developing MPM and compare the survival of patients with MPM to those with single primary melanomas (SPM), a prospective, multidisciplinary database of patients with melanoma at a single tertiary care institution was retrospectively reviewed. From 1985 to 2013, 6,963 patients with SPM and 305 patients with MPM were identified. Mean follow-up was 8.3 ± 6.3 years for patients with SPM, and 8.8 ± 5.9 years for patients with MPM. Researchers found:

  • Risk of developing multiple melanomas increased with age at diagnosis of first melanoma (HR = 1.20 for a 10-year increase in age), male sex (HR = 1.44), and white race (HR = 3.07).
  • Patients with invasive MPM had increased risk of melanoma-specific death both before (HR = 1.47), and after, adjusting for age, sex, site, race, family history of melanoma, personal history of other cancer, and Surveillance, Epidemiology, and End Results (SEER) stage (HR = 1.44).

Nosrati A, Yu WY, McGuire J, et al. Outcomes and risk factors in patients with multiple primary melanomas. [Published online ahead of print July 19, 2018]. J Invest Dermatol. doi:10.1016/j.jid.2018.07.009.