HLA antigen mismatch appears to be associated with reductions in the risk of skin cancer after solid-organ transplant among heart and lung transplant recipients, according to a recent retrospective cohort study. This finding suggests that HLA antigen mismatch activates the tumor surveillance mechanisms that protect against skin cancer in transplant recipients and that skin cancer risk may be higher in patients who received a well-matched organ. This study is a secondary analysis of the multicenter Transplant Skin Cancer Network study of adults who underwent a primary solid-organ transplant between January 1, 2003, and December 31, 2003, or between January 1, 2008, and December 31, 2008. Researchers found:
- In total, 10,649 organ transplant recipients contributed 59,923 years of follow-up.
- For each additional mismatched allele, a 7% to 8% reduction in skin cancer risk was found.
- Subgroup analysis found the protective effect of HLA antigen mismatch to be statistically significant in lung and heart transplant recipients but not for recipients of liver, kidney, or pancreas.
- The degree of HLA-DR mismatch, but not HLA-A or HLA-B mismatch, was the most statistically significant for skin cancer risk.
Gao Y, Twigg AR, Hirose R, et al. Association of HLA antigen mismatch with risk of developing skin cancer after solid-organ transplant. [Published online ahead of print January 23, 2019]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.4983.
This Week's Must Reads
Dietary Changes: No Major Effect on Psoriasis, Dermatol Online J; 2019 Feb 15; Pona, et al
Influenza Vaccine Rates in Adults with Psoriasis, J Invest Dermatol; 2019 Feb; Noe, Shin, et al
Psoriasis and AD Share Inflammatory Components, J Invest Dermatol; ePub 2019 Jan 11; Tsoi, et al
Quality of Life Among Patients with Psoriasis, PsA, Arch Dermatol Res; ePub 2019 Mar 13; Duvetorp, et al
Psoriasis and Cardiometabolic Comorbidity in Women, Acta Derm Venereol; 2019 Mar 1; Blegvad, et al
Must Reads in Melanoma
Melanoma Rates Before and After AJCC 7 Enactment, JAMA Dermatol; ePub 2019 Mar 6; Isom, et al
HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al
Poor Prognosis for Thin Ulcerated Melanomas Found, J Am Acad Dermatol; ePub 2019 Jan 14; Hawkins, et al
Cutaneous Nevi and Risk of Melanoma Examined, J Am Acad Dermatol; ePub 2019 Jan 10; Li, et al