Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Follicular Involvement Frequent in Lentigo Maligna

J Am Acad Dermatol; ePub 2018 Sep 26; Connolly, et al

Superficial follicular involvement is a ubiquitous finding in lentigo maligna (LM), according to a recent study. Therefore, when considering treatment options for LM with a depth-dependent modality aiming for tumor clearance, mean and maximum depths of involvement should be considered. Researchers conducted a single-center retrospective study of 100 consecutive cases of surgically excised LM treated from 2013 to 2015. Slide review for cases with residual LM on debulk specimen was performed by a dermatologic surgeon and dermatopathologist to characterize follicular involvement. They found:

  • 72 of 100 specimens met inclusion criteria for histopathologic evaluation.
  • Follicular involvement was seen in 95.8% of specimens, with a mean 68% of follicles involved in a single specimen.
  • The mean depth of intrafollicular growth by lesional melanocytes was 0.45 mm (SD=0.23, range 0.1 mm to 1.1 mm).
  • Tumor cells were confined to the infundibular portion of the hair follicle in 60.9% of specimens.
Citation:

Connolly KL, Giordano C, Dusza S, Busam KJ, Nehal K. Follicular involvement is frequent in lentigo maligna: Implications for treatment. [Published online ahead of print September 26, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.07.071.

This Week's Must Reads

Dietary Changes: No Major Effect on Psoriasis, Dermatol Online J; 2019 Feb 15; Pona, et al

Influenza Vaccine Rates in Adults with Psoriasis, J Invest Dermatol; 2019 Feb; Noe, Shin, et al

Psoriasis and AD Share Inflammatory Components, J Invest Dermatol; ePub 2019 Jan 11; Tsoi, et al

Quality of Life Among Patients with Psoriasis, PsA, Arch Dermatol Res; ePub 2019 Mar 13; Duvetorp, et al

Psoriasis and Cardiometabolic Comorbidity in Women, Acta Derm Venereol; 2019 Mar 1; Blegvad, et al

Must Reads in Melanoma

Melanoma Rates Before and After AJCC 7 Enactment, JAMA Dermatol; ePub 2019 Mar 6; Isom, et al

HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al

Poor Prognosis for Thin Ulcerated Melanomas Found, J Am Acad Dermatol; ePub 2019 Jan 14; Hawkins, et al

Cutaneous Nevi and Risk of Melanoma Examined, J Am Acad Dermatol; ePub 2019 Jan 10; Li, et al