Clinical Edge

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Lymecycline vs. clindamycin plus rifampicin for hidradenitis suppurativa

Key clinical point: Lymecycline appears to be more effective in “nodule-type” hidradenitis suppurativa (HS), and clindamycin plus rifampicin combination is more effective in “abscesses-tunnel type” HS.

Major finding: Nodule count reduction was higher with lymecycline vs. clindamycin plus rifampicin (53.7% vs. 42.1%; P less than .001). Decrease in the number of abscess (68.8% vs. 47%) and draining tunnels (13.8% vs. 0%) was statistically more with clindamycin plus rifampicin combination vs. lymecycline (P = .008).

Study details: The data come from a retrospective analysis of 52 HS patients divided into two groups of 26 patients receiving lymecycline and clindamycin plus rifampicin for 10 weeks.

Disclosures: No study sponsor was identified. The authors declared no conflicts of interest.


Caposiena Caro RD et al. Clin Exp Dermatol. 2020 Jul 19. doi: 10.1111/ced.14388.