Clinical Edge

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Hidradenitis suppurativa tied to increased risk of psychiatric and substance use disorders

Key clinical point: Patients with hidradenitis suppurativa (HS) have an increased likelihood of substance and alcohol abuse, psychiatric comorbidities and suicide.

Major finding: HS was significantly associated with increased risk for schizophrenia (odds ratio [OR], 1.66; P less than .00001), bipolar disorders (OR, 1.96; P less than .00001), depression (OR, 1.75; P less than .00001), anxiety (OR, 1.71; P less than .00001) personality disorders (OR, 1.50; P = .001), suicide (OR, 2.08; P = .004), substance use disorders (OR, 2.84; P less than .00001), and alcohol abuse (OR 1.94; P less than .0001).

Study details: The data come from a systematic review and meta-analysis of 12 articles.

Disclosures: The study was not funded. SD Smith reported ties with Abbvie. The other authors reported no conflicts of interest.


Phan K et al. Ann Transl Med. 2020 Jul. doi: 10.21037/atm-20-1028.