Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Association between hidradenitis suppurativa and Down syndrome

Key clinical point: This meta-analysis suggests an association between hidradenitis suppurativa (HS) and Down syndrome (DS), with early age of HS onset in patients with DS vs. those without.

Major finding: Pooled analysis of mean differences between DS and non-DS participants presenting with HS showed a significantly younger age of HS onset in DS vs. non-DS patients (−6.12; 95% confidence interval [CI], −10.01 to −2.24). Pooled analysis on the association between HS and DS demonstrated significantly increased odds of HS patients presenting with DS vs. controls (odds ratio, 9.61; 95% CI, 5.70-16.20).

Study details: A systematic review of 12 studies including 358 participants presenting with both HS and DS.

Disclosures: No study sponsor was identified. The authors declared no conflicts of interest.


Lam M et al. Pediatr Dermatol. 2020 Sep 6. doi: 10.1111/pde.14326.