Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Umbilical Cord Allograft May Boost Diabetic Foot Ulcer Healing

Key clinical point: Dehydrated human umbilical cord allograft may be more beneficial than alginate dressing in the healing of stubborn diabetic foot ulcers (DFUs).

Major finding: At 12 weeks, more ulcers healed completely in the allograft group than in the alginate group (70% vs. 48%, respectively; P = .0089).

Study details: Prospective, multicenter, randomized controlled trial that assigned 155 patients with persistent DFUs to either treatment.

Disclosures: The lead author, William Tettelbach, MD, is now an employee of MiMedx, which provided research funding to all of the authors.


Tettelbach W et al. Int Wound J. 2019;16(1):122-30. doi: 10.1111/iwj.12976.