Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Evaluation of Combined Detection Method for BCC

JAMA Dermatology; ePub 2018 Aug 22; Sahu, et al

Combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging may be prospectively used to comprehensively diagnose lesions suggestive of basal cell carcinoma (BCC), according to a recent study. This pilot study was carried out on patients referred for physician consultation or Mohs surgery at Memorial Sloan Kettering Skin Cancer Center. They underwent imaging, with the combined RCM-OCT probe, for previously biopsied, histopathologically confirmed BCCs and lesions clinically or dermoscopically suggestive of BCC. Researchers found:

  • In total, 85 lesions from 55 patients (27 [49%] were female and 28 [51%] were male with a median [range] age of 59 [21-90] years) were imaged.
  • Imaging was performed on 25 previously biopsied and histopathologically confirmed BCCs and 60 previously non-biopsied but clinically or dermoscopically suspicious lesions.
  • Normal skin and BCC features were correlated and validated with histopathologic examination.
  • In previously biopsied lesions, residual tumors were detected in 12 of 25 (48%) lesions with 100% sensitivity and 23.1% specificity for combined RCM-OCT probe.
  • In previously non-biopsied and suspicious lesions, BCCs were diagnosed in 48 of 60 (80%) lesions with 100% sensitivity and 75% specificity.

Sahu A, Yélamos O, Iftimia N, et al. Evaluation of a combined reflectance confocal microscopy–optical coherence tomography device for detection and depth assessment of basal cell carcinoma. [Published online ahead of print August 22, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.2446.