Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CD4 cells implicated in pathology of CCCA

Key clinical point: Langerhans cells in hair follicles have been found to sustain a CD4 cell-mediated inflammatory reaction that characterizes central centrifugal cicatricial alopecia (CCCA).

Major finding: Unlike many other forms of scarring alopecia, CCCA has a CD4-predominant lymphocytic inflammatory infiltrate.

Data Source: The study involved pathological examination of biopsy specimens of 18 black women with a known diagnosis of CCCA.

Disclosures: The authors did not list any disclosures. The funding source was listed as the Center for Scientific Review (Grant/Award).


Flamm A et al. J Cutan Pathol. 2020 Feb 18.doi: 10.1111/cup.13666.