Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

ALT-70 Gets High Marks for Diagnosing Cellulitis

J Am Acad Dermatol; ePub 2018 Jul 9; Li, et al

The ALT-70 predictive model for lower extremity cellulitis and thermal imaging outperformed thermal imaging in diagnosing lower extremity cellulitis, according to results of a recent evaluation. Furthermore, the accuracy of the ALT-70 was high and consistent with previously published reports. Broad implementation of ALT-70 into clinical practice may decrease misdiagnosis rates of lower extremity cellulitis. Researchers collected ALT-70 and thermal imaging data from patients with presumed lower extremity cellulitis and compared classification measures and accuracy for ALT-70, thermal imaging, and combination testing (ALT-70 plus thermal imaging). 67 patients with ALT-70 and thermal imaging data were enrolled. They found:

  • ALT-70 conferred the highest sensitivity (97.8%) and negative predictive value (90.9%), while combination testing had the highest specificity (71.4%) and positive predictive value (86.6%).
  • ALT-70 had improved classification measures compared to thermal imaging.
  • Combination testing conferred a marginal benefit to ALT-70 alone.

Citation:

Li DG, Dewan AK, Xia FD, Khosravi H, Joyce C, Mostaghimi A. The ALT-70 predictive model outperforms thermal imaging for the diagnosis of lower extremity cellulitis: A prospective evaluation. [Published online ahead of print July 9, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.06.062.

This Week's Must Reads

Racial Differences in Psoriasis Therapy Perceptions, J Invest Dermatol; ePub 2019 Feb 6; Takeshita, et al

Detecting Atherosclerotic Plaques in Psoriasis, PLoS One; ePub 2019 Feb 8; Gonzalez-Cantero, et al

Smoking, Not Alcohol, Linked with Psoriasis Risk, J Am Acad Dermatol; 2019 Mar; Dai, et al

Maternal Socioeconomic Position, Psoriasis Linked, Br J Dermatol; 2019 Feb; Groot, Nybo Andersen, et al

Psoriasis: A “Protective Effect” Against Allergens?, Br J Dermatol; 2019 Feb; Claßen, et al

Must Reads in Dermatopathology

Melanoma Risk and Moderately Dysplastic Nevi, JAMA Dermatol; ePub Oct 10; Kim, Berry, et al

Sentinel Lymph Node Positivity Markers in Melanoma, J Am Acad Dermatol; ePub 2018 Sep 18; Conic, et al

Recurrent Morphological Patterns in Melanomas, J Am Acad Dermatol; ePub Aug 27; Klebanov, et al

Evaluation of Combined Detection Method for BCC, JAMA Dermatology; ePub 2018 Aug 22; Sahu, et al

Pathology Methods for Melanocytic Lesions Compared, JAMA Dermatology; ePub 2018 Aug 15; Onega, et al