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ALT-70 Gets High Marks for Diagnosing Cellulitis

J Am Acad Dermatol; ePub 2018 Jul 9; Li, et al

The ALT-70 predictive model for lower extremity cellulitis and thermal imaging outperformed thermal imaging in diagnosing lower extremity cellulitis, according to results of a recent evaluation. Furthermore, the accuracy of the ALT-70 was high and consistent with previously published reports. Broad implementation of ALT-70 into clinical practice may decrease misdiagnosis rates of lower extremity cellulitis. Researchers collected ALT-70 and thermal imaging data from patients with presumed lower extremity cellulitis and compared classification measures and accuracy for ALT-70, thermal imaging, and combination testing (ALT-70 plus thermal imaging). 67 patients with ALT-70 and thermal imaging data were enrolled. They found:

  • ALT-70 conferred the highest sensitivity (97.8%) and negative predictive value (90.9%), while combination testing had the highest specificity (71.4%) and positive predictive value (86.6%).
  • ALT-70 had improved classification measures compared to thermal imaging.
  • Combination testing conferred a marginal benefit to ALT-70 alone.


Li DG, Dewan AK, Xia FD, Khosravi H, Joyce C, Mostaghimi A. The ALT-70 predictive model outperforms thermal imaging for the diagnosis of lower extremity cellulitis: A prospective evaluation. [Published online ahead of print July 9, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.06.062.