Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Pyoderma Gangrenosum and Underlying Diseases

Am J Clin Dermatol; 2018 Aug; Kridin, Cohen, et al

More than half of patients with pyoderma gangrenosum present with a relevant underlying disease, according to a recent study, with inflammatory bowel disease and arthritis the most frequently associated diseases. Relative to the reported literature, the pooled prevalence of arthritis and hematological malignancies is lower, while the pooled prevalence of solid malignancies is higher. Researchers performed a systematic literature review and meta-analysis of observational studies dated from 1823–2017. The quality of evidence was assessed using a modified Newcastle-Ottawa Scale. A meta-analysis was performed using random-effects models to estimate pooled prevalence rates with 95% confidence intervals. 21 eligible studies comprising 2,611 patients with pyoderma gangrenosum were included in the quantitative synthesis. They found:

  • The overall random-effects pooled prevalence of associated systemic diseases was 56.8%.
  • The leading underlying disease was inflammatory bowel disease (17.6%), followed by arthritis (12.8%), hematological malignancies (8.9%), and solid malignancies (7.4%).
  • In 16.3% of cases, the onset of pyoderma gangrenosum was attributed to the pathergy phenomenon.

Citation:

Kridin K, Cohen AD, Amber KT. Underlying systemic diseases in pyoderma gangrenosum: A systematic review and meta-analysis. Am J Clin Dermatol. 2018;19(4):479-487. doi:10.1007/s40257-018-0356-7.

This Week's Must Reads

Dietary Changes: No Major Effect on Psoriasis, Dermatol Online J; 2019 Feb 15; Pona, et al

Influenza Vaccine Rates in Adults with Psoriasis, J Invest Dermatol; 2019 Feb; Noe, Shin, et al

Psoriasis and AD Share Inflammatory Components, J Invest Dermatol; ePub 2019 Jan 11; Tsoi, et al

Quality of Life Among Patients with Psoriasis, PsA, Arch Dermatol Res; ePub 2019 Mar 13; Duvetorp, et al

Psoriasis and Cardiometabolic Comorbidity in Women, Acta Derm Venereol; 2019 Mar 1; Blegvad, et al

Must Reads in Autoimmune Diseases

List of medications linked to drug-induced lupus expands, Arnaud L et al. Ann Rheum Dis. 2019 Feb 4. doi: 10.1136/annrheumdis-2018-214598

Incidence of Oral SCC Risk in Oral Lichen Planus, Int J Dermatol; ePub 2018 Sep 14; Lanoisz, et al

HRQOL in Patients with Cutaneous T-Cell Lymphoma, Int J Dermatol; ePub 2018 Aug 3; Holahan, Farah, et al

Pyoderma Gangrenosum and Underlying Diseases, Am J Clin Dermatol; 2018 Aug; Kridin, Cohen, et al

Autoimmune Disease Risk in Patients with CLE, JAMA Dermatology; ePub 2018 May 2; Kunzler, et al