Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Pyoderma Gangrenosum and Underlying Diseases

Am J Clin Dermatol; 2018 Aug; Kridin, Cohen, et al

More than half of patients with pyoderma gangrenosum present with a relevant underlying disease, according to a recent study, with inflammatory bowel disease and arthritis the most frequently associated diseases. Relative to the reported literature, the pooled prevalence of arthritis and hematological malignancies is lower, while the pooled prevalence of solid malignancies is higher. Researchers performed a systematic literature review and meta-analysis of observational studies dated from 1823–2017. The quality of evidence was assessed using a modified Newcastle-Ottawa Scale. A meta-analysis was performed using random-effects models to estimate pooled prevalence rates with 95% confidence intervals. 21 eligible studies comprising 2,611 patients with pyoderma gangrenosum were included in the quantitative synthesis. They found:

  • The overall random-effects pooled prevalence of associated systemic diseases was 56.8%.
  • The leading underlying disease was inflammatory bowel disease (17.6%), followed by arthritis (12.8%), hematological malignancies (8.9%), and solid malignancies (7.4%).
  • In 16.3% of cases, the onset of pyoderma gangrenosum was attributed to the pathergy phenomenon.

Citation:

Kridin K, Cohen AD, Amber KT. Underlying systemic diseases in pyoderma gangrenosum: A systematic review and meta-analysis. Am J Clin Dermatol. 2018;19(4):479-487. doi:10.1007/s40257-018-0356-7.

This Week's Must Reads

Psoriasis Linked with Increased All-Cause Mortality, J Am Acad Dermatol; ePub 2018 Dec 24; Dhana, et al

Examining Patient Resistance to Psoriasis Treatment, Exp Opin Pharmacother; ePub 2018 Dec 27; Heath, et al

Psoriasis Linked with Periodontal Inflammation, J Invest Dermatol; ePub 2019 Jan 2; Woeste, et al

Psoriasis Independently Linked with Depression Risk, Br J Dermatol; 2019 Jan; Egeberg, Thyssen, Wu, et al

Health Literacy May Benefit Patients with Psoriasis, Br J Dermatol; ePub 2018 Dec 31; Larsen, et al

Must Reads in Autoimmune Diseases

Incidence of Oral SCC Risk in Oral Lichen Planus, Int J Dermatol; ePub 2018 Sep 14; Lanoisz, et al

HRQOL in Patients with Cutaneous T-Cell Lymphoma, Int J Dermatol; ePub 2018 Aug 3; Holahan, Farah, et al

Pyoderma Gangrenosum and Underlying Diseases, Am J Clin Dermatol; 2018 Aug; Kridin, Cohen, et al

Autoimmune Disease Risk in Patients with CLE, JAMA Dermatology; ePub 2018 May 2; Kunzler, et al

Underlying Disease Impact on Pyoderma Gangrenosum, J Am Acad Dermatol; ePub 2018 Feb 10; Kaffenberger, et al