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Incidence of Oral SCC Risk in Oral Lichen Planus

Int J Dermatol; ePub 2018 Sep 14; Lanoisz, et al

Patients with oral lichen planus (OLP), particularly the erosive type, have an increased incidence of oral squamous cell carcinoma (OSCC) development and should be monitored closely, according to a recent study. Researchers conducted a population‐based retrospective cohort study. Patients with OLP from 1986 through 2010 were identified using the Rochester Epidemiology Project (REP) for Olmsted County, MN. For each OLP case (n=303), they randomly selected 2 age‐ and gender‐matched referents (n=606). OLP diagnosis was established based on the World Health Organization (WHO) criteria. Medical records were reviewed for development of OSCC after the OLP diagnosis (index date). The association between OLP and development of OSCC was assessed. They found:

  • The overall incidence of OLP per 100,000 person‐years was 11.4.
  • Among the OLP cohort, 7 had OSCC (incidence of OSCC, 3.1%) at 20 years after OLP diagnosis.
  • 3 OSCC cases were identified among the referents.
  • Patients with OLP were 4.8 times more likely to have OSCC than the matched referents.
  • The median time to OSCC development was 14.7 years earlier for the OLP cohort.


Lanoisz V, Torgerson RR, Ramos-Rodriguez AJ, et al. Incidence of squamous cell carcinoma in oral lichen planus: A 25‐year population‐based study. [Published online ahead of print September 14, 2018]. Int J Dermatol. doi:10.1111/ijd.14215.