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Autoimmune Disease Risk in Patients with CLE

JAMA Dermatology; ePub 2018 May 2; Kunzler, et al

Patients with cutaneous lupus erythematosus (CLE) without concurrent systemic lupus erythematosus (SLE) can have increased rates of coexisting autoimmune conditions, a recent study found. Therefore, collecting a thorough review of systems can prompt clinicians to pursue further testing and evaluation by other specialists. This cross-sectional study was performed from November 2008 to February 2017 at the University of Texas Southwestern Medical Center (UTSW) and Parkland Health and Hospital System. Participants were identified through the UTSW Cutaneous Lupus Registry. All participants had a dermatologist-confirmed diagnosis of CLE using clinicopathological correlation. Exclusion criteria included age <18 years and meeting at least 4 American College of Rheumatology diagnostic criteria for SLE. Researchers found:

  • Among the 285 participants initially screened, 129 participants with CLE were included (102 [79.1%] female; median age, 49 years).
  • Coexisting autoimmune conditions were found in 23 (17.8%).
  • Autoimmune thyroid disease had the highest frequency at 4.7% (n=6).
  • Multivariable logistic regression analyses showed that patients with CLE who were white, never smokers, had family history of autoimmune disease, and history of positive antinuclear antibody test result had a significant association with having coexisting autoimmune conditions.


Kunzler E, Hynan LS, Chong BF. Autoimmune diseases in patients with cutaneous lupus erythematosus. [Published online ahead of print May 2, 2018]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.0616.