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Validation of Outcomes for AD Severity in Adults

Among multiple atopic dermatitis (AD) assessments, Patient-Oriented Scoring AD (PO-SCORAD), PO-SCORAD objective and subjective sub-scores, numerical rating scale (NRS)-itch, and patient-oriented eczema measure (POEM) appear to be valid for assessing AD severity in clinical practice. This according to a cross-sectional, population-based study of 2,893 adults, including 602 that met a modified UK Diagnostic Criteria for AD. AD severity was assessed using self-reported global AD severity. Researchers found:

  • PO-SCORAD, PO-SCORAD objective and subjective sub-scores and NRS-itch ad POEM all had moderate to strong correlations with each other.
  • Dermatology Life Quality Index (DLQI) had fair to moderate correlations with Hospital Anxiety and Depression Scale A (HADS-A) and HADS-D, and inverse correlations with short-form (SF)-12 MCS and SF-6D.
  • All scores showed good criterion validity.
  • PO-SCORAD, PO-SCORAD objective sub-scores, and POEM had similarly good internal consistency.

Citation:

Silverberg JI, Margolis DJ, Boguniewicz M, et al. Validation of five patient-reported outcomes for atopic dermatitis severity in adults. [Published online ahead of print April 19, 2019]. Br J Dermatol. doi: 10.1111/bjd.18002.